Tetrahydrofuran → HCID 21265710, compound

Participants

Reaction Steps

To the compound of Example 33 (0.100 g, 0.189 mmol) in THF (0.90 mL) were added nBu4NI (catalytic) and a trace of 18-crown-6. To this mixture at −78° C. was added potassium tert-butoxide (1M in THF, 0.208 mL) after a period of 10 min at −78° C., a THF solution (0.30 mL) of tert-butyl 2-[4-(bromomethyl)phenyl]-2,2-difluoroacetate](0.066 g, 0.206 mmol) was added. After a period of 2 h, at 0° C., the reaction mixture was quenched as described for Example 31 Step 1.

Provenance & Evidence