Butyl ether → HCID 45262091, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-chloro-4-(2-(diphenylamino)ethoxy)butane (2.0 g, 6.6 mmol), ethyl (R)-3-piperidinecarboxylate (1.1 g, 7.0 mmol), potassium carbonate (1.0 g, 7.2 mmol) and dry dibutylether was heated at 150° C. for 4 h. The mixture was cooled, filtered and the solvent evaporated in vacuo. The residue was submitted to flash chromatography on silica gel (150 g) using a mixture of n-heptane and THF (4:1) as eluent. This afforded 1.5 g (34% calculated from 2-(diphenylamino)ethanol) of

Provenance & Evidence