HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-cyanophenylboronic acid → Ethyl 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-3-methylbutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-cyanophenylboronic acid | HCID 46738934 | — |
| Reactant | Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-methylbutanoate | HCID 117622680 | — |
| Product | Ethyl 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]-3-methylbutanoate | HCID 117622646 | — |
Reaction Steps
240 mg (purity 92%, 0.73 mmol) of ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-methylbutanoate (racemate) and 172 mg (0.95 mmol) of 5-chloro-2-cyanophenylboronic acid in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/monodichloromethane adduct were reacted according to General Method 2A. Yield: 117 mg (purity 81%, 36% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-4a8deb7ad96640f09a7fa530f9ab9955 |
| Source note | uspto-grants-2016_09 |