Hydrochloric Acid → HCID 10788634, compound

Participants

Reaction Steps

(R)-1-(2-((2,2-bis(3-Methyl-2-thienyl)ethenyl)oxy)ethyl)3-piperidinecarboxylic ethyl ester (420 mg, 1 mmol, Example 65) was dissolved in ethanol (20 ml) and 10 N sodium hydroxide solution (1.00 ml) was introduced. After 3 h at room temperature the pH of the solution was adjusted to 9 with 2 N hydrochloric acid. The ethanol was removed by evaporation and the pH of the solution was adjusted to 2.5. Extraction with dichloromethane (4×15 ml), drying of the combined extracts (MgSO4) and evaporation of the filtrate provided a residue, which was recrystallized from water. This provided the title compound (0.34 g, 84%) as a cream solid.

Provenance & Evidence