HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → Ethyl 2-(4-iodo-2-oxopyridin-1(2H)-yl)hexanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Ethyl 2-bromohexanoate | HCID 79072 | — |
| Reactant | Lithium Bromide | HCID 82050 | — |
| Reactant | 4-Iodo-1,2-dihydropyridin-2-one | HCID 20582535 | — |
| Product | Ethyl 2-(4-iodo-2-oxopyridin-1(2H)-yl)hexanoate | HCID 117622881 | — |
Reaction Steps
500 mg (2.3 mmol) of 4-iodopyridin-2(1H)-one and 706 mg (3.2 mmol) of ethyl 2-bromohexanoate (racemate) in the presence of 1.15 eq. of sodium hydride and 2.3 eq. of lithium bromide were reacted according to General Method 4C. Yield: 352 mg (43% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-e224993d741441e4a7233bc3c8509374 |
| Source note | uspto-grants-2016_09 |