HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-cyanophenylboronic acid → Ethyl 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]hexanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-cyanophenylboronic acid | HCID 46738934 | — |
| Reactant | Ethyl 2-(4-iodo-2-oxopyridin-1(2H)-yl)hexanoate | HCID 117622881 | — |
| Product | Ethyl 2-[4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]hexanoate | HCID 117622689 | — |
Reaction Steps
150 mg (0.41 mmol) of ethyl 2-(4-iodo-2-oxopyridin-1(2H)-yl)hexanoate (racemate) and 97 mg (0.53 mmol) of 5-chloro-2-cyanophenylboronic acid in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. Yield: 114 mg (purity 95%, 70% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-28b76e6515d14df6b8c23a7fd3699f0a |
| Source note | uspto-grants-2016_09 |