Methanol → HCID 9846179, compound

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	Sodium	HCID 5360545	—
Reactant	[[3-(2-amino-1,2-dioxoethyl)-1-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-1H-indol-4-yl]oxy]acetic acid methyl ester	HCID 10575769	—
Solvent	Sodium Hydroxide	HCID 14798	—
Product	HCID 9846179	HCID 9846179	77.1%

Reaction Steps

Using the procedure described in Example 2, Part E, 803 mg (1.8 mmol) of [[3-(2-amino-1,2-dioxoethyl)-1-([1,1′-biphenyl]-4-ylmethyl)-2-methyl-1H-indol-4-yl]oxy]acetic acid methyl ester was hydrolyzed in 10 mL of 1N NaOH and 20 mL of MeOH to give 614 mg (74% yield) of [[3-(2-amino-1,2-dioxoethyl)-1-([1,1′-biphenyl]-4-ylmethyl)-2-methyl-1H-indol-4-yl]oxy]acetic acid, sodium salt, mp, >265° C.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06175021B1
Source dataset	uspto-grants-2001_01
ORD ID	ord-cf260df647c441eeb158908133144d02
Source note	uspto-grants-2001_01