HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-methoxy-2-methyl-1-[(1-naphthalenyl)methyl]-1H-indole → 4-hydroxy-2-methyl-1-[(1-naphthalenyl)methyl]-1H-indole
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-methoxy-2-methyl-1-[(1-naphthalenyl)methyl]-1H-indole | HCID 10638039 | — |
| Edukt | Boron tribromide dichloromethane | HCID 22277759 | — |
| Lösungsmittel | Ethyl acetate hexane | HCID 21226206 | — |
| Produkt | 4-hydroxy-2-methyl-1-[(1-naphthalenyl)methyl]-1H-indole | HCID 10493529 | 71% |
Reaktionsschritte
By the method used in Example 1, Part D, 1.17 g (3.9 mmol) of 4-methoxy-2-methyl-1-[(1-naphthalenyl)methyl]-1H-indole was O-demethylated by treating it with 15.6 mL of 1M BBr3/CH2Cl2 to give a material that was chromatographed on silica gel (eluted with 20% EtOAc/hexane then 50% EtOAc/hexane) to give 796 mg (71% yield) of 4-hydroxy-2-methyl-1-[(1-naphthalenyl)methyl]-1H-indole.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06175021B1 |
| Quelldatensatz | uspto-grants-2001_01 |
| ORD ID | ord-afe31506700142c8840ede957dfd19f0 |
| Quellennotiz | uspto-grants-2001_01 |