Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2-(Tert-butoxycarbonylamino)-5-methoxyphenyl]-2-butanone → 2-ethyl-5-methoxy-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2-(Tert-butoxycarbonylamino)-5-methoxyphenyl]-2-butanone | HCID 10517825 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Trifluoroacetic acid | HCID 6422 | — |
| 생성물 | 2-ethyl-5-methoxy-1H-indole | HCID 10702405 | 58% |
반응 단계
1-[2-(tert-Butoxycarbonylamino)-5-methoxyphenyl]-2-butanone (7.33 g, 0.025 mol) in 120 mL of CH2Cl2 and 20 mL of trifluoroacetic acid was stirred for 20 hours, washed with water, NaHCO3 solution and the product chromatographed on silica (eluted with 20% EtOAc/hexane) to give 2.54 g (58% yield) of 2-ethyl-5-methoxy-1H-indole as a white solid, mp 49-50° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06175021B1 |
| 출처 데이터셋 | uspto-grants-2001_01 |
| ORD ID | ord-376b64dfc1264f5fa41a03829842dd7c |
| 출처 메모 | uspto-grants-2001_01 |