HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 56669Generated: October 25, 2026
Sodium hydride → Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-phenylpropanoate
https://huagongshe.com/reaction/56669
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Lithium Bromide | HCID 82050 | — |
| Reactant | 4-Bromo-2-hydroxypyridine | HCID 817115 | — |
| Reactant | Ethyl 2-bromo-3-phenylpropanoate | HCID 4737529 | — |
| Product | Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-yl)-3-phenylpropanoate | HCID 117622558 | — |
Reaction Steps
544 mg (3.13 mmol) of 4-bromopyridin-2(1H)-one and 845 mg (3.3 mmol) of ethyl 2-bromo-3-phenylpropanoate (racemate) in the presence of 1.15 eq. of sodium hydride and 2.3 eq. of lithium bromide were reacted according to General Method 4C (stirred at 65° C. for 1.5 h). Yield: 572 mg (51% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09434690B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-2da1cfbee0a04af5a39d8083688e43f8 |
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| Source note | uspto-grants-2016_09 |
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