Imidazole → HCID 131722274, compound

Participants

Reaction Steps

To a stirred solution of 4-pyridylcarbinol (21.8 g, 0.20 mole) in DMF (200 mL) at 25° C. was added imidazole (15.64 g, 0.23 mole) and t-butyldimethylsilyl chloride (31.65 g, 0.21 mole). The reaction mixture was allowed to stirred at that temperature for 3 hr. Standard aqueous work up (ethyl acetate extraction, washed with water and brine, dried with MgSO4, evaporation), followed by chromatographic purification (silica gel, hexane/ethyl acetate) gave the title compound. 1H-NMR (CDCl3, 400 MHz) δ: 8.50(d, 2H), 7.25(d, 2H), 4.86(s, 2H), 0.90(s, 9H), 0.05(s, 6H).

Provenance & Evidence