Lithium Hydroxide → HCID 21266518, compound

Participants

Reaction Steps

To a solution of 5-acetoxy-5-m-tolyl-5,6-dihydro-1H-[4,4′]bipyridinyl-2-one (322 mg, 1.0 mmole) in THF (5 mL) and water (5 mL) at r.t. was added LiOH (126 mg, 3.0 mmole) in one portion. The reaction mixture was stirred at that temperature for 1 hr before quenching the mixture with aqueous NH4Cl. Standard work up (extraction of compound with methylene chloride), followed by purification (methano/methylene chloride) gave the title compound. MS (m/z): Calcd. C17H16N2O2(M+): 280, found (M+H)+: 281.0.

Provenance & Evidence