Sulfuric Acid → HCID 21266526, compound

Participants

Reaction Conditions

Reaction Steps

Preparation of 4-(3-methylphenyl)-5-(4-pyridyl)-1H-pyrid-one To a solution of 6-hydroxy-4-m-tolyl-5,6-dihydro-1H-[5,4′]bipyridinyl-2-one (83 mg, 0.29 mmole) in CHCl3 (3 mL) at r.t. was added 2 ml of conc. H2SO4. The resulting mixture was heated to 55° C. for 2 hr. The mixture was cooled down to r.t. and was carefully quenched with aqueous sodium carbonate. Standard work up (extraction of compound with methylene chloride), followed by purification (silica gel, methanol/methylene chloride) gave the title compound.

Provenance & Evidence