HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-(trifluoromethyl)phenylboronic acid → Ethyl {4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-(trifluoromethyl)phenylboronic acid | HCID 46736817 | — |
| Reactant | Ethyl 2-(4-bromo-2-oxopyridin-1(2H)-YL)acetate | HCID 71009808 | — |
| Product | Ethyl {4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}acetate | HCID 117622823 | — |
Reaction Steps
2.04 g (7.8 mmol) of ethyl (4-bromo-2-oxopyridin-1(2H)-yl)acetate and 1.98 g (8.6 mmol) of 5-chloro-2-trifluoromethylphenylboronic acid in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. Yield: 2.89 g (quant.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-cf808488f41d45298c92203087c7c70a |
| Source note | uspto-grants-2016_09 |