Triphenylphosphine → HCID 54298263, compound

Participants

Reaction Steps

To a stirred mixture of 4-(3-methylphenyl)-5-(4-pyridyl)-1H-pyrid-2-one (12 mg, 0.05 mmole), (S)-2-tert-butoxycarbonylamino-3-phenylpropanol (15 mg, 0.06 mmole), triphenylphosphine (18 mg, 0.07 mmole), in methylene chloride (1 mL) at room temperature was added diethyl azodicarboxylate (12 mg, 0.07 mmol). When the reaction was complete (monitored by TLC), methanol was added (1 mL) and the reaction was concentrated and treated with 1 mL of 1:1 TFA/methanol for 30 minutes. The mixture was concentrated, neutralized with 1 drop conc NH4OH, and purified (SiO2, 10% methanol/methylene chloride) to give the title compound: MS (m/z): Calcd. C26H25N3O (M+): 395, found (M+H)+: 396.

Provenance & Evidence