Water → N-(2,2-dimethyl-1(S)-(methylcarbamoyl)propyl)-3(R)-(3-phenyl-1H-pyrrol-1-yl)succinamic acid benzyl ester

HRID 566741Notes

Reaction equation

HRID 566741 reaction equation
FC(F)(F)C(O)=O.[CH2:8]([O:15][C:16](=[O:32])[CH2:17][C@@H:18]([NH2:31])[C:19]([NH:21][C@H:22]([C:27](=[O:30])[NH:28][CH3:29])[C:23]([CH3:26])([CH3:25])[CH3:24])=[O:20])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.CO[CH:35]1[CH:39]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)[CH2:38][CH:37](OC)O1.FC(F)(F)C(O)=O.O>ClCCCl>[CH2:8]([O:15][C:16](=[O:32])[CH2:17][C@@H:18]([N:31]1[CH:37]=[CH:38][C:39]([C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=2)=[CH:35]1)[C:19]([NH:21][C@H:22]([C:27](=[O:30])[NH:28][CH3:29])[C:23]([CH3:25])([CH3:26])[CH3:24])=[O:20])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 185488262,5-Dimethoxy-3-phenyltetrahydrofuranHCID 700814343(r)-Amino-n-(2,2-dimethyl-1(s)-(methylcarbamoyl)propyl)succinamic acid benzyl ester trifluoroacetate salt

Product 1

HCID 15459665N-(2,2-dimethyl-1(S)-(methylcarbamoyl)propyl)-3(R)-(3-phenyl-1H-pyrrol-1-yl)succinamic acid benzyl esterYield 37%

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

A solution of crude 3(R)-amino-N-[2,2-dimethyl-1(S)-(methylcarbarnoyl)propyl]-succinamic acid benzyl ester trifluoroacetate salt (2.33 mmol), 2,5-dimethoxy-3-phenyl-tetrahydrofuran (583 mg, 2.80 mmol), trifluoroacetic acid (216 μL, 2.80 mmol), and water (50 μL, 2.8 mmol) in 1,2-dichloroethane (1 mL) was heated at 70° C. After 20 hours, the mixture was allowed to cool and concentrated in vacuo to give a brown oil, which was purified via flash column chromatography with 0.5% HOAc/35% EtOAc/hex as eluant to afford 407 mg (37%) of N-(2,2-dimethyl-1(S)-(methylcarbamoyl)propyl)-3(R)-(3-phenyl-1H-pyrrol-1-yl)succinamic acid benzyl ester as a yellow foam. 1H NMR: ∂ 7.52-7.44 (m, 2H), 7.38-7.15 (m, 3H), 7.04 (dd, 1H, J=1.8, 1.8 Hz), 6.78 (t, 1H, J=2.5 Hz), 6.56 (dd, 1H, J=1.6, 2.5 Hz), 6.42 (d, 1H, J=9.0 hz), 5.95 (bd, J=4.0 Hz), 5.18-5.04 (m, 3H), 4.30 (d, 1H, J=9.0 Hz), 3.38 (dd, 1H, J=5.9, 16.8 Hz), 3.10 (dd, 1H, J=8.4, 16.8 hz), 2.72 (d, 3H, J=5.0 Hz), 0.93 (s, 9H). IR: 3301, 2960, 1736, 1645, 1542, 1166, 752, 695 cm−1. HRFABMS: Calculated for C28H33N3O4Cs (M+Cs+): 608.1525. Found: 608.1549. Anal. Calculated for C28H33N3O4•0.2 H2O: C, 70.18; H, 7.03; N, 8.77. Found: C, 70.45; H, 6.99; N, 8.84.

Workup

  1. temperatureto cool
  2. concentrationconcentrated in vacuo
  3. customto give a brown oil, which
  4. customwas purified via flash column chromatography with 0.5% HOAc/35% EtOAc/hex as eluant

Sources & evidence

ORD record
ord-34ea7ab8416740b1abd83244d1c909ef
Source dataset
uspto-grants-2001_01
Patent number
US06174915B1

Reaction notes

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