Benzoic acid, 4-amino-, 1,1-dimethylethyl ester → tert-Butyl 4-{[2-{4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}-3-(pyridin-3-yl)propanoyl]amino}benzoate

Participants

Reaction Steps

26 mg (purity 92%, 0.06 mmol) of 2-{4-[5-chloro-2-(trifluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}-3-(pyridin-3-yl)propanoic acid (racemate) and 1.1 eq. of tert-butyl 4-aminobenzoate were reacted according to General Method 5A. The reaction mixture was freed from DMF and the residue was stirred with ice-water. The crystals obtained were filtered off, washed with water and dried under reduced pressure. Yield: 33 mg (purity 94%, 92% of theory)

Provenance & Evidence