Solketal → HCID 10488217, compound

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Reaction Steps

The 2-methyl-3-hydroxypyridine-4(1H)-one of glycerol is prepared starting from the 2-methyl-3-hydroxypyridine-4(1H)-one of solketal according to the method described in example 15. The extraction and purification protocol is the following: filtration of the catalyst, addition of water, followed by elimination of the organic solvent, lyophilization, retake-up of the residue by an organic solvent, neutralization using Dowex OH− resin, filtration, and finally evaporation of the solvent. Starting from 1.00 g (3.04 mmol) of 2-methyl-3-benzyloxypyridine-4(1H)-one of solketal, 790 mg (2.73 mmol) of 2-methyl-3-hydroxypyridine-4(1H)-one of glycerol is isolated, which is pure at chromatographic and NMR analyses. Yield: 90%.

Provenance & Evidence