Benzoyl chloride → HCID 69284610, compound

Participants

Reaction Conditions

Reaction Steps

v)—A solution of the alcohol 6 (132.5 g) obtained in the previous step in dry pyridine (1310 ml) was cooled to 0° C. Benzoyl chloride (65.7 ml) was added in 5 min. and the reaction mixture was stirred for 1 h at room temperature. Then it was poured into ice-water (6650 ml) and the resulting suspension was stirred over-night. The precipitate was collected by filtration and washed with water (40-50° C.). The residue was dried and purified by crystallization from acetone to give (3β,20S)-21-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4,20-trimethylpregn-5-en-3-ol benzoate (7) (113.6 g).

Provenance & Evidence