Ethyl 5-formylisoxazole-3-carboxylate → 5-Formyl-1,2-oxazole-3-carboxylic acid

Participants

Reaction Steps

A solution of ethyl-5-formylisoxazole-3-carboxylate (25 mg) in 1,4-dioxan (3 ml) and 2M hydrochloric acid (1 ml) was stirred and heated at reflux for 5 h.; cooled and the solvents removed in vacuo. The residue was triturated in diethyl ether. The solvent was removed and the residue dried to leave the title compound (18 mg) as an orange/brown solid.

Provenance & Evidence