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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 566900Generated: October 31, 2026

Methanol → HCID 9955004, compound

https://huagongshe.com/reaction/566900

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantSodiumHCID 5360545—
ReactantHCID 10503986HCID 10503986—
SolventSodium HydroxideHCID 14798—
ProductHCID 9955004HCID 995500443.4%

Reaction Steps

A mixture of 956 mg (2.1 mmol) of ((3-(2-amino-1,2-dioxoethyl)-1-((1,1′-biphenyl)-3-ylmethyl)-2-methyl-1H-indol-4-yl)oxy)acetic acid methyl ester is hydrolyzed at reflux in 10 mL of 1N NaOH and 20 mL of MeOH to give 403 mg (41% yield) of ((3-(2-amino-1,2-dioxoethyl)-1-((1,1′-biphenyl)-3-ylmethyl)-2-methyl-1H-indol-4-yl)oxy)acetic acid, sodium salt, mp, greater than 265° C. Analyses for C26H21N2O5Na:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06177426B1
Source datasetuspto-grants-2001_01
ORD IDord-f41c907edfe244cba5fdf026918ebc7c
Source noteuspto-grants-2001_01