(2-Hydroxy-5-methoxyphenyl)boronic acid → 6-(2-Hydroxy-5-methoxyphenyl)-6'-(2-hydroxy-4-methylphenyl)-2,2'-bipyridine

Participants

Reaction Steps

6-(2-Hydroxy-5-methoxyphenyl)-6′-(2-hydroxy-4-methylphenyl)-2,2′-bipyridine was prepared from 6-bromo-6′-(2-hydroxy-4-methylphenyl)-2,2′-bipyridine and 2-hydroxy-5-methoxyphenylboronic acid in 28% yield using method F; δH [2H6]-DMSO 13.70,(1H, b), 12.57,(1H, b), 8.38,(1H, d), 8.31,(1H, 8,25-8.17,(2H, m), 8.12,(1H, d), 8.02,(1H, d), 7.65,(1H, d), 7.00,(1H, dd), 6.94,(1H, d), 6.82,(2H, m), 3.82,(3H, s), 2.33,(3H, s); MS 385 (MH)+; HPLC retention time (system 1) 4.28 minutes.

Provenance & Evidence