3-Fluoro-2-hydroxybenzeneboronic acid → 6-(3-Fluoro-2-hydroxyphenyl)-6'-(2-hydroxy-4-methylphenyl)-2,2'-bipyridine

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Reaction Steps

6-(3-Fluoro-2-hydroxyphenyl)-6′-(2-hydroxy-4-methylphenyl)-2,2′-bipyridine was prepared from 6-bromo-6′-(2-hydroxy-4-methylphenyl)-2,2′-bipyridine and 3-fluoro-2-hydroxyphenylboronic acid in 17% yield using method F; δH [2H6]-DMSO 13.37,(1H, b), 8.38,(1H, d), 8.34-8.15,(4H, m), 8.10,(1H, d), 8.01,(1H, d), 7.95,(1H, d), 7.34,(1H, t), 6.98,(1H, m), 6.81,(2H, m), 2.33,(3H, s).

Provenance & Evidence