(2-Hydroxy-5-methylphenyl)boronic acid → 6-(2-Hydroxy-4-methylphenyl)-6'-(2-hydroxy-5-methylphenyl)-2,2'-bipyridine

Participants

Reaction Steps

6-(2-Hydroxy-4-methylphenyl)-6′-(2-hydroxy-5-methylphenyl)-2,2′-bipyridine was prepared from 6-bromo-6′-(2-hydroxy-4-methylphenyl)-2,2′-bipyridine and 5-methyl-2-hydroxyphenylboronic acid in 44% yield using method F; δH [2H6]-DMSO 13.60,(1H, b), 13.10,(1H, b), 8.32,(2H, t), 8.23,(2H, m), 8.13,(2H, d), 8.03,(1H, d), 7.95,(1H, s), 7.18,(1H, d), 6.92,(1H, d), 6.83,(2H, m), 2.33,(3H, s), 2.34,(3H, s); MS 369 (MH)+; HPLC retention time (system 1) 4.46 minutes.

Provenance & Evidence