(2-Hydroxy-5-methoxyphenyl)boronic acid → 6-(2-Hydroxy-3-methoxyphenyl)-6'-(2-hydroxy-5-methoxyphenyl)-2,2'-bipyridine

Participants

Reaction Steps

6-(2-Hydroxy-3-methoxyphenyl)-6′-(2-hydroxy-5-methoxyphenyl)-2,2′-bipyridine was prepared from 6-bromo-6′-(2-hydroxy-3-methoxyphenyl)-2,2′-bipyridine and 2-hydroxy-5-methoxyphenylboronic acid in 16% yield using method F; δH [2H6]-DMSO 13.72,(1H, b), 12.48,(1H, b), 8.39,(1H, d), 8.32,(1H, d), 8,27-8.14,(4H, m), 7.72,(1H, d), 7.67,(1H, s), 7.09,(1H, d), 7.04-6.90,(3H, m), 3.86,(6H, s); MS 401 (MH)+; HPLC retention time (system 1) 3.98 minutes.

Provenance & Evidence