(2-Hydroxy-3,4-dimethylphenyl)boronic acid → 6-(3,4-Dimethyl-2-hydroxyphenyl)-6'-(2-hydroxy-3-methoxyphenyl)-2,2'-bipyridine

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Reaction Steps

6-(3,4-Dimethyl-2-hydroxyphenyl)-6′-(2-hydroxy-3-methoxyphenyl)-2,2′-bipyridine was prepared from 6-bromo-6′-(2-hydroxy-3-methoxyphenyl)-2,2′-bipyridine and 3,4-dimethyl-2-hydroxyphenylboronic acid in 11% yield using method F; δH [2H6]-DMSO 13.32,(1H, s), 8.38-8.22,(4H, m), 8.14,(1H, d), 8.10,(1H, d), 7.88,(1H, d), 7.72,(1H, d), 7.10,(1H, d), 6.94,(1H, t), 6.82,(1H, d), 3.84,(3H, s), 2.31,(3H, s), 2.20,(3H, s); MS 339 (MH)+; HPLC retention time (system 1) 4.39 minutes.

Provenance & Evidence