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5-Fluoro-2-hydroxyphenylboronic acid → 6-(5-Fluoro-2-hydroxyphenyl)-6'-(2-hydroxy-5-methoxyphenyl)-2,2'-bipyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Fluoro-2-hydroxyphenylboronic acid | HCID 3772476 | — |
| 反応物 | 6-Bromo-6'-(2-hydroxy-5-methoxyphenyl)-2,2'-bipyridine | HCID 135854285 | — |
| 生成物 | 6-(5-Fluoro-2-hydroxyphenyl)-6'-(2-hydroxy-5-methoxyphenyl)-2,2'-bipyridine | HCID 135528965 | 50% |
反応手順
6-(5-Fluoro-2-hydroxyphenyl)-6′-(2-hydroxy-5-methoxyphenyl)-2,2′-bipyridine was prepared from 6-bromo-6′-(2-hydroxy-5-methoxyphenyl)-2,2′-bipyridine and 5-fluoro-2-hydroxyphenylboronic acid in 50% yield using method F; δH [2H6]-DMSO 13.09,(1H, b), 12.63,(1H, b), 8.36,(2H, m), 8.22,(4H, m), 7,99,(1H, d), 7.64,(1H, s), 7.22,(1H, t), 7.05-6.91,(3H, m), 3.80,(3H, s).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06177419B1 |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-8201b70c2ef8401f9592b2011013d977 |
| 出典メモ | uspto-grants-2001_01 |