反应详情

A mixture of 2,2-difluorosuccinic acid (1.15 g, 7.46 mmol), thionyl chloride (4 mL, 20.6 mmol) and benzene (4 mL) was heated at reflux for 2.5 h. The mixture was filtered and the filtrate was concentrated to afford the title product as an oil that crystallized on standing (838 mg, 6.16 mmol, 83% yield).

1. temperaturewas heated
2. temperatureat reflux for 2.5 h
3. filtrationThe mixture was filtered
4. concentrationthe filtrate was concentrated