HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromopropionic acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromopropionic acid | HCID 11729 | — |
| Reactant | 4-Chloro-2-(5-chloro-2-oxo-1,2-dihydropyridin-4-yl)benzonitrile | HCID 117605221 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 2-[5-Chloro-4-(5-chloro-2-cyanophenyl)-2-oxopyridin-1(2H)-yl]propanoic acid | HCID 117622549 | — |
Reaction Steps
910 mg (purity 57%, 1.96 mmol) of 4-chloro-2-(5-chloro-2-oxo-1,2-dihydropyridin-4-yl)benzonitrile and 1.5 eq. of 2-bromopropanoic acid (racemate) were reacted according to General Method 4A, initially at RT for 2.5 h and then at 45° C. overnight. The desired product was obtained by precipitation with hydrochloric acid. Yield: 1.06 g (purity 78%, quant.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-3bf6cf3c49e5403095b732419e13cb77 |
| Source note | uspto-grants-2016_09 |