HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Benzyloxy-5-methyl-benzo[de]isoquinoline-1,3-dione → 2-Hydroxy-5-methyl-benzo[de]isoquinoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Benzyloxy-5-methyl-benzo[de]isoquinoline-1,3-dione | HCID 22624050 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 2-Hydroxy-5-methyl-benzo[de]isoquinoline-1,3-dione | HCID 22623940 | 33.9% |
Reaction Steps
The hydrogenation of 2-benzyloxy-5-methyl-benzo[de]isoquinoline-1,3-dione (0.4 g, 1.3 mmol, from Example P) was performed in the presence of 10% Pd/C (0.1 g) in DMA (20 mL). Purification of crude product by column chromatography (silica gel using 10% methanol in dichloromethane) gave 0.1 g of the title compound, mp 251-253° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06177423B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-5a3499d06dd642daa8627a549c673f5a |
| Source note | uspto-grants-2001_01 |