N-bromobutanimide → HCID 22624027, compound

Participants

Reaction Steps

A mixture of 2-hydroxy-6-methoxy-benzo[de]isoquinoline-1,3-dione (0.12 g, 0.5 mmol, from Example 17) and N-bromosuccinimide (0.13 g, 0.7 mmol) in acetic acid (20 mL) was sonicated at 60° C. for 24 hours. The mixture was transferred to a preheated oil bath at 100° C. with vigorous stirring for another 24 hours. The precipitate was filtered, washed with water, dried, and recrystallized from methanol to give 0.05 g of the title compound, mp 223-227° C.;

Provenance & Evidence