HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetate → 5-Bromo-2-hydroxy-7-(piperidin-1-yl)-benzo[de]isoquinoline-1,3-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetate | HCID 84468 | — |
| Reactant | 2-Benzyloxy-5-bromo-7-(piperidin-1-yl)-benzo[de]isoquinoline-1,3-dione | HCID 22623897 | — |
| Reactant | HCID 178525683 | HCID 178525683 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 5-Bromo-2-hydroxy-7-(piperidin-1-yl)-benzo[de]isoquinoline-1,3-dione | HCID 22623925 | 28.1% |
Reaction Steps
Following the procedure of Example 52, 2-benzyloxy-5-bromo-7-(piperidin-1-yl)-benzo[de]isoquinoline-1,3-dione (0.090 g, 0.19 mmol, from Example T1-B), and a 1.0 M solution of boron tris(trifluoroacetate) in TFA (2 mL) were reacted to give 0.020 g of the title compound as the trifluoroacetate salt, mp 134-136° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06177423B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-45118b03fd384c5f88035b3715fe33bb |
| Source note | uspto-grants-2001_01 |