反应详情

30 g of 6-benzyloxy-2,2-dimethylchroman-4-one oxime were dissolved in 900 ml of THF/methanol (1:1), treated with 25 ml of aqueous ammonia and hydrogenated in a shaking duck with Raney Ni. The catalyst was then filtered off with suction, the filtrate was concentrated in vac., the residue was dissolved in EA, the solution was dried and concentrated, and the residue was crystallized using petroleum ether, 22.9 g , m.p. 86-88° C.

1. filtrationThe catalyst was then filtered off with suction
2. concentrationthe filtrate was concentrated in vac
3. dissolution, the residue was dissolved in EA
4. customthe solution was dried
5. concentrationconcentrated
6. customthe residue was crystallized