反应详情

12 g of N-[6-benzyloxy-2,2-dimethylchroman-4-yl]-N-ethylmethanesulfonamide were dissolved in 250 ml of THF/methanol (1:1) and hydrogenated in a shaking duck using Pd/carbon. After absorption of hydrogen was complete, the catalyst was filtered off with suction, the filtrate was concentrated and the residue was crystallized using diisopropyl ether, 7.7 g, m.p. 169-170° C.

1. customAfter absorption of hydrogen
2. filtrationthe catalyst was filtered off with suction
3. concentrationthe filtrate was concentrated
4. customthe residue was crystallized