HuagongsheHuagongshe Chemistry Print Report · For research reference only
n-[6-Benzyloxy-2,2-dimethylchroman-4-yl]-n-methylmethanesulfonamide → N-[2,2-dimethyl-6-hydroxychroman-4-yl]-N-methylmethanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | n-[6-Benzyloxy-2,2-dimethylchroman-4-yl]-n-methylmethanesulfonamide | HCID 21264508 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | N-[2,2-dimethyl-6-hydroxychroman-4-yl]-N-methylmethanesulfonamide | HCID 21264510 | — |
Reaction Steps
7.3 g of N-[6-benzyloxy-2,2-dimethylchroman-4-yl]-N-methylmethanesulfonamide were dissolved in 100 ml of THF/methanol (1:1) and hydrogenated in a shaking duck using Pd/carbon. After absorpt ion of hydrogen was complete, the catalyst was filtered off with suction, the filtrate was concentrated and the residue was crystallized using dhsopropyl ether/petroleum ether, 5.2 g, m.p. 159-161° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06177449B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-0facdb0dc0644252a943aadc07e22562 |
| Source note | uspto-grants-2001_01 |