2-Thiopheneboronic acid → HCID 86756255, compound

Participants

Reaction Conditions

Reaction Steps

410 mg (1 mmol) of ethanesulfonic acid (6-iodo-2,2-dimethylchroman-4-yl)methylamide were dissolved in 5 ml of toluene and 130 mg (1 mmol) of thiopheneboronic acid, 40 mg of palladium tetrakis(triphenylphosphine) in 5 ml of ethanol and 1.1 ml of 2-molar cesium carbonate solution were added. The mixture was stirred overnight at 80° C. After removing the solvent, the residue was taken up in methylene chloride and washed with water. After drying and removing the solvent, the residue obtained was purified by column chromatography (eluent heptane/ethyl acetate 1:1), and 260 mg (71 %) of ethanesulfonic acid (2,2-dimethyl-6-thiophen-2-yl-chroman-4-yl)methylamide were obtained as an oil.

Provenance & Evidence