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HRID56708

反应详情

EQUATION

反应方程式

HRID 56708 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)c1ccc(N)cc1
HCID233272

tert-Butyl 4-aminobenzoate

C11H15NO2

结构：CC(C(=O)O)n1cc(Cl)c(-c2cc(Cl)ccc2C(F)F)cc1=O
HCID117622899

未命名化合物

PRODUCTS

生成物

1
结构：CC(C(=O)Nc1ccc(C(=O)OC(C)(C)C)cc1)n1cc(Cl)c(-c2cc(Cl)ccc2C(F)F)cc1=O
HCID117622840

未命名化合物

PROCEDURE

实验过程

115 mg (0.32 mmol) of 2-{5-chloro-4-[5-chloro-2-(difluoromethyl)phenyl]-2-oxopyridin-1(2H)-yl}propanoic acid (racemate) and 1.2 eq. of tert-butyl 4-aminobenzoate were reacted according to General Method 5A. After work-up, the crude product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient). Yield: 79 mg (46% of theory)

WORKUP

后处理

  1. customAfter work-up, the crude product was purified by preparative HPLC (Reprosil C18, water/acetonitrile gradient)