HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzeneethanamine, 4-nitro-, hydrochloride (1:1) → (s)-1-Phenoxy-3-[[2-(4-nitrophenyl)ethyl]amino]-2-propanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzeneethanamine, 4-nitro-, hydrochloride (1:1) | HCID 458983 | — |
| Reactant | (2S)-2-(phenoxymethyl)oxirane | HCID 1534345 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | (s)-1-Phenoxy-3-[[2-(4-nitrophenyl)ethyl]amino]-2-propanol | HCID 53932073 | 39.3% |
Reaction Steps
7.71 g of (S)-2-phenoxymethyloxirane and 10.34 g of 2-(4-nitrophenyl)ethylamine hydrochloride were subjected to a ring-opening reaction in the presence of 5.20 g of triethylamine to obtain 6.35 g of (S)-1-phenoxy-3-[[2-(4-nitrophenyl)ethyl]amino]-2-propanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06177454B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-2ee66b0f78b84c239bb91ff1932ac374 |
| Source note | uspto-grants-2001_01 |