HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 21264429, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 2777349 | HCID 2777349 | — |
| Reactant | 4-[2-(Dimethylamino)ethoxy]benzoic acid--hydrogen chloride (1/1) | HCID 13174871 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 21264429 | HCID 21264429 | — |
Reaction Steps
Similarly as described in example 22 using a solution of 4-(4-trifluoromethoxyphenyl)-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine in N,N-dimethylformamide (0.375 M, 0.4 ml, 0.15 mmol), a suspension of 4-(2-dimethylaminoethoxy)benzoic acid hydrochloride in N,N-dimethylformamide (0.375 M, 0.4 ml, 0.15 mmol), triethylamine (42 pi), and 0.25 ml of a suspension of N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride in dichloromethane (1.73 g in 8.3 ml) affords the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06177443B1 |
| Source dataset | uspto-grants-2001_01 |
| ORD ID | ord-af2dfd2cac8d47949eca3157a43d9e2a |
| Source note | uspto-grants-2001_01 |