HCID 21264460, compound → HCID 21264437, compound

Participants

Reaction Steps

The above dimethyl-{4-[(2-thiophen-2-yl-ethylimino)-methyl]-phenyl}-amine (1 g, 3.9 mmol) was added TFA (20 mL) at once (strongly exothermic reaction). The reaction mixture was stirred at room temperature for 72 hours, then evaporated in vacuo. The crude oil was suspended in dichloromethane (75 ml) and extracted with 1 N hydrochloric acid (50 ml). The aqueous phase was added 2 N sodium hydroxide to pH=10, then extracted with dichloromethane (3×125 ml). The organic phase was dried with MgSO4, filtered, evaporated in vacuo to afford 0.96 g (95%) of the title compound.

Provenance & Evidence