Pyridinium hydrochloride → HCID 117605519, compound

HRID 56716Notes

Reaction equation

HRID 56716 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:18]([F:20])[F:19])=[C:6]([C:8]2[CH:13]=[C:12]([O:14]C)[N:11]=[CH:10][C:9]=2[C:16]#[N:17])[CH:7]=1.Cl.[NH+]1C=CC=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:18]([F:20])[F:19])=[C:6]([C:8]2[C:9]([C:16]#[N:17])=[CH:10][NH:11][C:12](=[O:14])[CH:13]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 21584435Pyridinium hydrochlorideHCID 117605435HCID 117605435, compound

Product 1

HCID 117605519HCID 117605519, compound

Procedure

143 mg (purity 65%, 0.32 mmol) of 4-[5-chloro-2-(difluoromethyl)phenyl]-6-methoxypyridin-3-carbonitrile and pyridinium hydrochloride were reacted according to General Method 3A. Yield: 88 mg (99% of theory)

Sources & evidence

ORD record
ord-7b05d846176e477e9debaa1cf25cef63
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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