Benzoic acid, 4-amino-, 1,1-dimethylethyl ester → HCID 117622717, compound

HRID 56718Notes

Reaction equation

HRID 56718 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:22]([F:24])[F:23])=[C:6]([C:8]2[C:13]([C:14]#[N:15])=[CH:12][N:11]([CH:16]([CH3:20])[C:17](O)=[O:18])[C:10](=[O:21])[CH:9]=2)[CH:7]=1.[NH2:25][C:26]1[CH:38]=[CH:37][C:29]([C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])=[CH:28][CH:27]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:22]([F:24])[F:23])=[C:6]([C:8]2[C:13]([C:14]#[N:15])=[CH:12][N:11]([CH:16]([CH3:20])[C:17]([NH:25][C:26]3[CH:38]=[CH:37][C:29]([C:30]([O:32][C:33]([CH3:34])([CH3:35])[CH3:36])=[O:31])=[CH:28][CH:27]=3)=[O:18])[C:10](=[O:21])[CH:9]=2)[CH:7]=1

Participants

3

Reactant 2

HCID 233272Benzoic acid, 4-amino-, 1,1-dimethylethyl esterHCID 117622834HCID 117622834, compound

Product 1

HCID 117622717HCID 117622717, compound

Procedure

88 mg (purity 92%, 0.23 mmol) of 2-{4-[5-chloro-2-(difluoromethyl)phenyl]-5-cyano-2-oxopyridin-1(2H)-yl}propanoic acid (racemate) and 1.1 eq. of tert-butyl 4-aminobenzoate were reacted according to General Method 5A. Yield: 48 mg (36% of theory)

Sources & evidence

ORD record
ord-f532172692c44228a45e8e9b68597d73
Source dataset
uspto-grants-2016_09
Patent number
US09434690B2

Reaction notes

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