Deoxyhumulone → HCID 54356806, compound

Participants

Reaction Steps

In 22.0 ml of ethanol, 1.50 g (4.34 mmol) of {3,5-bis(3-methyl-2-butenyl)-2,4,6-trihydroxyphenyl} (2-methylpropyl) ketone (15) was dissolved. The solution was stirred with 924 mg (0.217 mmol, 5% equivalent) of 5% palladium carbon catalyst (water content up to 50%) under hydrogen atmosphere under ordinary pressure at room temperature for two hours. The solution was filtered and concentrated under a reduced pressure to form a brown oil. This oil was subjected to silica gel chromatography (using 100 g of Wako Gel C-200, eluted with hexane:ethyl acetate=10:1) to obtain 1.32 g (yield 86.6%) of the product (37) in the form of a colorless oily substance.

Provenance & Evidence