反应详情

1.0 g (purity 77%, 3.87 mmol) of 4-bromo-6-oxo-1,6-dihydropyridin-3-carbonitrile and 1.5 eq. of 2-bromopropanoic acid (racemate) were reacted according to General Method 4A at 35-45° C. After aqueous work-up, the crude product was triturated with cyclohexane/dichloromethane, and the solid was filtered off and dried under high vacuum. Yield: 648 mg (purity 66%, 41% of theory)

1. customaccording to General Method 4A at 35-45° C
2. customAfter aqueous work-up, the crude product was triturated with cyclohexane/dichloromethane
3. filtrationthe solid was filtered off
4. customdried under high vacuum