HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2-cyanophenylboronic acid → 4-Chloro-2-[5-(difluoromethyl)-2-methoxypyridin-4-yl]benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2-cyanophenylboronic acid | HCID 46738934 | — |
| Reactant | 5-(Difluoromethyl)-4-iodo-2-methoxypyridine | HCID 117605752 | — |
| Product | 4-Chloro-2-[5-(difluoromethyl)-2-methoxypyridin-4-yl]benzonitrile | HCID 117604879 | — |
Reaction Steps
616 mg (purity 83%, 1.79 mmol) of 5-(difluoromethyl)-4-iodo-2-methoxypyridine and 325 mg (1.79 mmol) of 5-chloro-2-cyanophenylboronic acid in the presence of [1,1-bis(diphenylphosphino)ferrocene]palladium(II) chloride/dichloromethane monoadduct were reacted according to General Method 2A. Yield: 223 mg (42% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434690B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-904989de005b4bff9637fe666df1165f |
| Source note | uspto-grants-2016_09 |