Tetrahydrofuran → HCID 21304103, compound

Participants

Reaction Steps

Platinum oxide (30 mg) was added to a stirred THF (30 mL) solution containing the compound of Example 58 (120 mg, 0.262 mmol) under a nitrogen atmosphere. The mixture was then stirred under a hydrogen atmosphere for 30 minutes. After filtration and concentration, the residue was chromatographed on silica (gradient 0-6% methanol in methylene chloride) to afford the subtitled compound (117 mg, 97%) as a white solid. IR (KBr) 3364, 3166, 1758, 1742, 1642 cm−1; 1H-NMR (CDCl3): δ 0.91 (t, J=7.4 Hz, 3H, —CH3), 1.57-1.65 (m, 2H), 3.40 (t, J=6.6 Hz, 2H, —OCH2—), 3.83 (s, 3H, —OCH3), 4.60 (s, 2H, —OCH2—), 4.91 (s, 2H, —OCH2—), 5.52 (s, 2H, —NCH2—), 5.95 (br s, 1H, —NH), 6.06 (br s, 1H, —NH), 6.58 (s, 1H), 7.04 (s, 1H), 7.07-7.10 (m, 2H), 7.20-7.41 (m, 6H); ESIMS m/e 461 (M++1).

Provenance & Evidence