反应详情

温度

6.5 °C

Sodium azide (160 kg) was dissolved in deionized water (505 L) and the solution was cooled to 3-10° C. To the solution was dropped trioctyltin chloride [TOTC] (847 kg) for 1-3 hours and the solution was stirred at 5-10° C. for about 2 hours. The reaction solution was extracted with methylene chloride (1822 kg, followed by 546 kg). The methylene chloride layer was washed with a mixture of deionized water (50 L) and 10% sodium chloride solution (440 L) and concentrated under reduced pressure to give trioctyltin azide [TOTA].

1. extractionThe reaction solution was extracted with methylene chloride (1822 kg, followed by 546 kg)
2. washThe methylene chloride layer was washed with a mixture of deionized water (50 L) and 10% sodium chloride solution (440 L)
3. concentrationconcentrated under reduced pressure