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HRID567434

反应详情

EQUATION

反应方程式

HRID 567434 的结构方程式

REACTANTS

反应物

2
结构：O=C(Cl)/C=C/c1ccoc1
HCID22736687

未命名化合物

结构：COc1ccc2c3c1O[C@H]1[C@H](S)CC[C@@]4(O)[C@@H](C2)N(CC2CC2)CC[C@]314
HCID86756291

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc2c3c1O[C@H]1[C@H](SC(=O)/C=C/c4ccoc4)CC[C@@]4(O)[C@@H](C2)N(CC2CC2)CC[C@]314
HCID86756290

未命名化合物

收率 59%

PROCEDURE

实验过程

The procedure of Example 11 was repeated, except that 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-mercaptomorphinan(K. Kanematsu, T. Toshiyasu, M. Yoshida., Chem., Pharm. Bull., 38, 1141, (1990)) was used instead of 17-cyclopropylmethyl-4,5α-epoxy-3,14β-dihydroxy-6α-(N-methylamino)morphinan 4 and trans-3-(3-furyl)acryloyl chloride was used instead of 3,4-dichlorophenylacetyl chloride, thereby preparing 17-cyclopropylmethyl-4,5α-epoxy-14β-hydroxy-3-methoxy-6β-[trans-3-(3-furyl)acryloylthio]morphinan 169 (yield: 59%).