Methanol → HCID 13796792, compound

Participants

Reaction Steps

To 400 ml of a methanol solution having 5.7 wt % potassium hydroxide, 50 g of the compound 6 and 49.1 g of 4-hydroxy-4′-cyanobiphenyl were added, followed by reflux. After they were completely reacted, water and dichloromethane were added thereto, and the organic layer was extracted. Then, saturated aqueous sodium chloride was added thereto, and the organic layer was extracted, followed by washing with water. Anhydrous magnesium sulfate was added thereto, the mixture was subjected to filtration under reduced pressure, and the filtrate was extracted. The filtrate was subjected to column chromatography by using dichloromethane as a developing solution, and dichloromethane was distilled off at 30° C. to obtain powder crystals. n-Hexane was added thereto to conduct recrystallization, and 40.0 g of the compound 7, i.e. 4-(3-hydroxypropyloxy)-4′-cyanobiphenyl was obtained.

Provenance & Evidence