HCID 178418361, compound → HCID 178515274, compound

Participants

Reaction Steps

To 2-(4-chlorophenyl)-2,5-dihydropyrazolo[4,3-c]cinnolin-3-one (0.5 g) dissolved in trifluoroacetic acid (20 ml) was added platinum oxide (0.2 g). The re action mixture was hydrogenated at 50 psi until no further uptake of hydrogen was observed. The catalyst was collected by filtration, the filtrate was poured onto ice and basified with ammonia. On the addition of dichloromethane a solid precipitated out; the solid was collected by filtration, washed with water and dried. Recrystallisation from ethanol gave the title compound. δH (360 MHz; DMSO-d6) 1.83 (4H, m, CH2), 2.67 (2H, t, J=5.7 Hz, CH2), 2.75 (2H, t, J=5.7 Hz, CH2), 7.51 (2H, d, J=9 Hz, ArH), 8.23 (2H, d, J=9 Hz, ArH), m/z (ESP+) 301/303 (MH+).

Provenance & Evidence